A vaccine against elephant endotheliotropic herpesvirus (EEHV), a disease that can kill young elephants within 24 hours of symptoms, is ready for wider use, researchers announced on Friday (October 3).

Chester

A vaccine developed to combat elephant endotheliotropic herpes virus (EEHV), a disease that can kill young elephants rapidly, is now prepared for broader application following successful proof-of-concept trials. The trials, conducted by Chester Zoo, the University of Surrey, and the Animal and Plant Health Agency, demonstrated that the vaccine is safe and induces strong immune responses in elephants.

The vaccine was initially tested on adult elephants with prior exposure to EEHV, as the disease is most dangerous for calves with undeveloped immune systems. The researchers are now focusing on vaccinating young elephants most at risk, with ongoing efforts to address legal and logistical challenges for wider distribution, particularly in zoos, sanctuaries, and range countries.

Vaccine for fatal elephant virus ready for wider use, researchers say

A vaccine against a disease capable of killing young elephants within 24 hours of symptoms is ready for wider use following successful trials, scientists say. Elephant endotheliotropic herpes virus, or EEHV, is endemic in elephants and can cause fatal hemorrhagic disease. Fatal cases have been reported in India, Nepal, Myanmar and Thailand, as well as in conservation breeding programs, according to Chester Zoo, the University of Surrey and the Animal and Plant Health Agency. The groups announced on Friday a proof-of-concept trial found the vaccine against EEHV was safe and triggered strong immune responses. Katie Edwards is lead conservation scientist at Chester Zoo and co-author of the study. We're basically at that stage now where we've got the scientific data that really supports our approach and shows the strength of the immune response that this vaccine can generate. So we're now at the stage where we are looking to use the vaccine in the young elephants that really need it the most. Because EEHV can't be grown in a lab, scientists use tiny pieces made only when the virus is copying itself inside an elephant's cell. The fragments train T-cells, the immune system's hunters, to identify and destroy infected cells early. Edwards says initial tests involved adult elephants that had prior exposure to the virus. In adult elephants, it doesn't tend to cause many problems. It's something that once they've become infected with, they can kind of almost keep that infection under control themselves. The challenge comes when we have young elephants that have got kind of an immune system that doesn't know how to recognize that virus yet. The group behind the vaccine said it was designed for use in zoos and sanctuaries. And that work is underway on delivery options suitable for range countries. The researchers said the next phase will prioritize vaccinating calves most at risk and navigating legal and logistical steps to supply doses more widely.

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Jerusalem

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Breakdown