More than 7 million Americans live with Alzheimer's. Dr. Jon LaPook discusses new tools and treatments that could change the course of the disease.

A couple, Carla and Marty Minor, shared their experience with Alzheimer's disease after Carla was diagnosed by a neurologist. Historically, both patients and physicians have been hesitant to diagnose Alzheimer's due to limited treatment options. However, a new drug called Lekembe, recently approved for use, offers potential benefits by removing amyloid plaques in the brain, which are associated with the disease. Clinical studies have shown that Lekembe can slow mental decline by about 30% over 18 months in early-stage patients.

Despite its promise, Lekembe and similar treatments carry FDA black box warnings due to risks of brain swelling and bleeding, necessitating regular MRI monitoring. Carla has received several infusions and remains independent, though it is too early to determine the treatment's effectiveness for her. The new medication represents a significant step forward in Alzheimer's care, offering renewed hope for patients and their families.

New advances offer hope in Alzheimer's detection and treatment

Oh my, Marty. Carla and Marty Minor have traveled the world together, married 44 years. Look how young you look there. They recently visited Bhutan. We have a great time together. Three years ago, Marty noticed Carla occasionally repeated what she'd already told him. I didn't know if it was stuff that's happening because we're getting older. A neurologist diagnosed Carla with Alzheimer's. It was horrible. You know, I'm not going to have that. I don't want that. Some patients and physicians have been reluctant to diagnose Alzheimer's because there have been few treatment options. Are things different now because there finally is a medication that could potentially make a difference? There's finally a medicine that you can show is different from placebo. Dr. Sam Gandy, a professor of neurology at Mount Sinai School of Medicine, offered Carla a drug called Lekembe. It's an intravenous infusion of one of two drugs approved within the last three years to treat the disease. It removes plaques in the brain called amyloid, a protein associated with Alzheimer's. So the red blobs are where the amyloid is. Dr. Gandy has done consulting for the company that makes Lekembe. In patients with the early stages of Alzheimer's, studies showed the drug slowed mental decline by about 30% after about 18 months. Both treatments carry FDA black box warnings on the risk of swelling and bleeding in the brain. Occasionally there will be some swelling, in some cases to the point maybe of even some bleeding. So we do surveillance MRIs regardless of whether there are symptoms or not. How does that feel? Carla Minor has had seven infusions over five months. It's too soon to tell if the treatment is working, but she's currently independent, enjoying time with her husband, and still able to channel her favorite singer. I know all the lyrics to a lot of those old rock and roll songs that I used to listen to. You ain't nothing but a... Hound dog! Alright! I'm hopeful. I have a wonderful life. We've just been very, very lucky. Hopefully this will be lucky too.

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Jerusalem

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Kyiv

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Breakdown