Eli Lilly on Thursday said its blockbuster diabetes drug Mounjaro showed heart health benefits in a late-stage trial directly comparing it to the company’s older diabetes treatment, Trulicity.

Eli Lilly announced that its diabetes medication Mounjaro reduced the risk of cardiovascular events in people with type 2 diabetes, meeting the primary goal of a phase three trial. The study compared Mounjaro directly with Eli Lilly's older drug, Trulicity, and found that Mounjaro delivered an 8% lower rate of cardiovascular events and a 16% reduction in death from any cause compared to Trulicity.

Despite these positive results, some experts noted that the benefits were not substantially greater than those seen with Trulicity, which may affect insurance coverage decisions, particularly in the United States. Full trial results are expected to be presented at an upcoming medical meeting, which may provide further clarity on the drug's impact.

Eli Lilly's Mounjaro shows heart health benefits in head-to-head trial

He's from Eli Lilly, which I don't know, Angelica, on the face, it looks positive. Why is the stock getting crushed? Yeah, Joe, so it's a little complicated, but here's what's going on. Lily is saying that it's diabetes drug Mounjaro cut the risk of heart disease, meeting the goal of a phase three trial in people with type two diabetes. Now, this trial was a head to head study looking at Mounjaro, and it provided a similar heart benefit as Lily's older GLP one trulicity. And the study was designed to show that Mounjaro isn't any worse than trulicity. And Mounjaro met that bar, delivering an eight percent lower rate of cardiovascular events than trulicity and a 16 percent reduction in death from any cause. Now, Lily has evidence that Mounjaro benefits the heart. So that's good. But that alone isn't surprising to doctors, since other GLP ones have already shown that they can do that. But these data do give Lily that proof. And they think that that strengthens the case for insurers, particularly in other parts of the world where they are launching that drug. But one doctor I talked to worries that these results aren't good enough to convince insurers, and at least here in the U.S., and that these results might actually limit coverage of Mounjaro since it wasn't significantly better than trulicity. We'll learn more when Lily presents the full results at a medical meeting in September. But like you said, that's talked down about four percent right now, Joe. Yeah, it's coming back a little. I don't know based on what it's thin, thinly traded pre-market, but if it had been, I think the result, there's definitely some disappointment. And as you said, some questions about, you know, about coverage, given that it wasn't, you know, it could have been. What would have been a great number? Do you think, Angelica, what were they looking for? So at least one analyst I was looking at are some of the notes ahead of this. They wanted to see greater than a 10 percent reduction in that cardiovascular event. So things like stroke, heart attack. And so you're seeing eight percent. And it's a little complicated, Joe. You know it. I know it. But this non-inferiority. So they needed to show that it wasn't any worse than trulicity. But and but people were expecting that it would hit that. And they didn't show that it was enough to say it's actually better than trulicity. And so that was the base case is what we got, which is fine. But people wanted to see more, especially as they try and go out and make that case. So, again, there's a lot more that people want to see when we do get those full results. But again, Lily is also quite happy with these. So we'll have to see what they say. So they say, yeah. There's another story. Yeah, there's another story out today, Angelica. Plastic surgeons. Business is booming because of ozempic face. Is there a way to play? Did you know is there there's no roll up plastic surgery? I mean, is there a way to go long ozempic face? Do you know? I don't want that. I really. I'm not sure that everybody does. People get it. We've talked about it, right? They lose skin and everything. Maybe some Botox. Maybe you want to invest in AbbVie. I'm not sure, but that's not a not an area that I can comment on. I never thought Angelica would say that to me. Maybe some Botox. Thank you.

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Breakdown