El Dr. Jon LaPook informa sobre los resultados de nuevos ensayos clínicos que sugieren que algunos pacientes de cáncer podrían evitar la quimioterapia, la radioterapia y la cirugía gracias a los prometedores avances en inmunoterapia.

In a notable advancement in cancer treatment, recent findings from an immunotherapy clinical trial suggest that some cancer patients may be able to forego traditional treatments such as chemotherapy, radiation, and surgery. The research, led by Dr. Andrea Sersek at Memorial Sloan-Kettering Cancer Center, holds promise for individuals with solid tumors. Notably, an individual with kidney cancer observed complete eradication of the tumor after six months of immunotherapy, according to the clinical trial's results.

The immunotherapy works by leveraging the body's own immune system to attack cancer cells. Dr. Jon LaPook explains that cancer cells typically find ways to evade immune responses. The new therapy removes these defense mechanisms, enabling a more effective immune system attack. This approach appears to be substantially beneficial, with 80% of trial participants requiring no further treatment beyond immunotherapy.

This clinical trial initially included individuals with rectal cancer, and now encompasses cancers of the esophagus, stomach, and urethra. Results have been particularly compelling, showing a complete resolution in early cases. While the trial does not entirely eliminate the necessity for surgery, it offers less invasive options by sufficiently shrinking tumors, thereby making surgery less severe and reducing recovery times. However, ongoing funding for such trials is crucial to sustaining research progress.



Un avance en inmunoterapia ofrece nuevas esperanzas a los enfermos de cáncer

En el Observatorio de la Salud de hoy, una importante actualización de una historia que le trajimos por primera vez en 2022 sobre un nuevo y prometedor enfoque para el tratamiento de ciertos tipos de cáncer. El pasado fin de semana, los científicos dieron a conocer los últimos resultados de un ensayo clínico de inmunoterapia que podría ayudar a algunos pacientes con cáncer a evitar tratamientos tóxicos como la quimioterapia, la radioterapia y la cirugía. El Dr. John LaPook está aquí con la actualización. John, buenos días. Buenos días, Brianna. Buenos días, Vlad. Estos resultados de la Dra. Andrea Sersek y su equipo del Memorial Sloan-Kettering Cancer Center amplían el número de personas con tumores sólidos a las que se podría ayudar utilizando únicamente inmunoterapia. Pacientes como Bruce Nollmeyer, que vio desaparecer su cáncer de riñón tras sólo seis meses de inmunoterapia. Asombroso. Hicieron una tomografía computarizada, y volvieron y dijeron que no veían el tumor. Y cuando oíste eso, ¿qué pensaste? No podía creer que funcionara tan rápido, para ser honesto. ¿Qué porcentaje no necesitó más tratamiento? El 80% no necesitó ningún tratamiento adicional. Así que ni cirugía, ni quimio, ni radiación, sólo inmunoterapia. Vaya. Para el público que no sepa qué es exactamente, ¿cómo funciona la inmunoterapia? Básicamente se trata de aprovechar tu sistema inmunológico, ¿verdad? Una célula cancerosa es anormal y normalmente el sistema inmunitario puede reconocerla. Entonces, la célula inmune se acerca, va a atacarla, y entonces la célula cancerosa tiene una forma elegante de decir, no tan rápido. Se pone los frenos en él. Y lo que hace este anticuerpo, este tipo de terapia, es quitarle el freno para que el sistema inmunitario pueda atacarlo y matarlo. Es simplemente impresionante. ¿Cómo de grande es este avance? ¿Es este el tipo de gran momento que hemos estado esperando en la investigación del cáncer? Ya sabes, esto es algo incremental. Llevamos mucho tiempo intentando aprovechar el sistema inmunitario. Se pone mejor y mejor y mejor, más específico. Este tipo de resultados no tienen precedentes, son espectaculares. Hace dos años y medio, hicimos el primer informe sobre esto con Andrea, la Dra. Andrea Sersak. Y había 18 personas que tenían cánceres rectales tempranos. Soy gastroenteróloga. Estoy mirando esta foto de un gran cáncer de recto, de aspecto desagradable, que se desvaneció por completo. 18 de 18 resuelto completamente. ¿Cómo? Y en este ensayo, 103 personas, dijeron, por qué no lo probamos con otros cánceres, no sólo de recto, de esófago, de estómago, y uretral, así que, ya sabes, los riñones. Y alrededor del 80% de las personas, no el 100%, el 80% de las personas no necesitaron ningún tratamiento adicional. Iba a decir, no necesitas la quimio, no necesitas la radiación si estás haciendo esta inmunoterapia, al menos en este caso. Sí, y piensa en ello, en lo que eso significa. Así que incluso si no desaparece totalmente, si sólo reduce el cáncer, y digamos que tienes un cáncer de esófago, eso es una gran cirugía si tienes que quitar parte del esófago y parte del estómago. Bueno, si es mucho más pequeño, la operación es menos drástica y la gente puede funcionar mejor después. Y la gente puede evitar la quimioterapia y la radiación, que sabemos que son tan duras de soportar y tan insultantes cuando la gente ya está luchando contra el cáncer. ¿Tenemos tiempo para otra pregunta sobre financiación? ¿Cómo es, ya sabes, la financiación está siendo amenazada para los ensayos como este, ¿cómo va a ser afectado? Oh, creo que, ya sabes, te preocupas por esto. Tienes un joven investigador como el Dr. Sursak, ese tipo de investigación necesita financiación. Y sabes, el comienzo de la investigación para esto empezó hace más de 100 años, no sucede de la noche a la mañana. Así que realmente tienes que apoyarlo. Mira a Kelly Spill, que es nuestra mujer de hace dos años y medio, ahora tiene dos hijos y otro en camino cerca del Día de la Madre, y chico, esa es toda la recompensa que necesitas. Nos encanta que esté aquí, Dr. LaPouf. Gracias, Dr. LaPouf. Noticias médicas muy, muy prometedoras. Muchas gracias.

It was not clear if Hamas’ statement meant it had accepted the proposal from US President Donald Trump for a 60-day ceasefire.

Jerusalem

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Washington

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Heavy rainfall in central Texas caused the Guadalupe River to overflow and unleash a torrent of water. The bodies of at least 13 children and adults have been recovered and more than 20 girls are missing from a sleepaway camp.

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Kyiv

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U.S. President Donald Trump marked the passage of the new spending bill, which includes changes to food assistance, student loan programs, and clean energy credits. Robert Costa joins "CBS Mornings" to break down what's in the legislation.

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Ukrainian President Volodymyr Zelenskyy said Kyiv will do "anything" to advance EU accession talks. Zelenskyy spoke alongside Danish Prime Minister Mette Frederiksen, President of the European Council António Costa and President of the European Commission Ursula von der Leyen.

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President Donald Trump said Washington will start sending letters to countries on Friday specifying what tariff rates they will face on imports to the United States, a clear shift from earlier pledges to strike scores of individual deals.

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Indonesian rescuers on Thursday (July 3) temporarily halted a search for 30 people still missing after a ferry carrying 65 people sank near the island of Bali with the loss of six lives, the national search and rescue agency said.

Gilimanuk

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After marathon debate sessions in the Senate and House, President Donald Trump’s budget bill passed in the House. Republicans secured the biggest win of Trump’s presidency.

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Florida says the first group of migrant detainees have arrived at the new immigration detention center known as "Alligator Alcatraz." CBS News correspondent Shanelle Kaul has more.

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U.S. President Donald Trump said Thursday (July 3) that he spoke with Russian President Vladimir Putin and that he plans to hold a call with Ukrainian President Volodymyr Zelenskyy. CBS News White House reporter Willie James Inman has more.

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CNN’s Priscilla Alvarez reports on a lawsuit from lawyers for Kilmar Abrego Garcia alleging he suffered “torture and mistreatment” after he was wrongfully deported and held in El Salvador’s notorious mega prison.

Tecoluca

Kilmar Abrego Garcia claims he was tortured in El Salvadoran prison

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Democratic leader Hakeem Jeffries spoke for hours on the House floor about potential impacts of President Trump's "big, beautiful bill" that Republicans are looking to pass before July 4. Following debate, the House is set for a final vote on the massive budget bill.

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Manhattan

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Liverpool soccer player Diogo Jota has died aged 28, just weeks after marrying his childhood sweetheart. The footballer passed away in a car crash in northern Spain.

Madrid

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The Pentagon said that U.S. strikes 10 days ago had degraded Iran's nuclear program by up to two years, suggesting the U.S. military operation likely achieved its goals despite a far more cautious initial assessment that leaked to the public.

Tehran

Iran Strikes

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Days before his 90th birthday, the Dalai Lama announced the Gaden Phodrang Trust, a non-profit he founded, will have the sole authority to recognize his future reincarnation, but China insists it will choose the successor of the Tibetan spiritual leader.

Lhasa

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The U.S. Congress inched towards approving President Donald Trump’s Big Beautiful Bill, despite attempts by Democrats to stop it. The bill is Trump’s signature legislation which includes massive spending increases on the military and immigration enforcement while slashing social programs.

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Sean (Diddy) Combs was found guilty on prostitution-related charges, but was acquitted on more serious charges of racketeering and sex trafficking giving him a maximum sentence of 20 years. But the courtroom victory was subdued following a judge’s ruling to deny him bail.

New York

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President Trump says Israel has agreed to a 60-day ceasefire in Gaza, but it remains unclear if Hamas will accept the terms. CBS News senior foreign correspondent Debora Patta has more.

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Bryan Kohberger changed his plea to guilty Wednesday for the 2022 murders of four University of Idaho students. CBS News national correspondent Carter Evans has more on the case.

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The Wisconsin Supreme Court struck down a state abortion law that was adopted in 1849 in a 4-3 landmark decision. CBS News' Shanelle Kaul reports.

Madison

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Everglades

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The U.S. Senate passed the Republicans' reconciliation bill on Tuesday (July 1) after more than 24 hours of marathon voting on amendments. Vice President JD Vance cast the tie-breaking vote.